Project 1. Neural oscillations in visual-cognitive deficits

This project will use state-of-the-art neuroimaging tools combined with a computational model to examine the underlying mechanisms associated with cognitive and behavioral effects of prenatal alcohol exposure gaining insight from the other center projects. The long-term goal is to understand the neurophysiological underpinnings of cognitive deficits to guide treatment development for individuals affected by prenatal alcohol exposure.​ ​

Neural Oscillations in Adolescents with FASD​

• Investigating alpha (attention-related) and gamma (information processing) oscillations.​
• Assessing their role in visual cognitive deficits and executive function.​

Cognitive Tasks and Neural Responses​

• Utilizing set-shifting and visual spatial working memory tasks to elicit neural oscillations.​
• Aligning with cognitive tasks used in preclinical projects​
• Set-shifting is evaluated based on persistent deficits highlighted in recent studies.​

Computational Modeling​

• Employing a computational model to simulate population responses measured by magneto-encephalography.​
• Evaluating brain dynamics alterations due to prenatal alcohol exposure.​

Interaction of Prenatal Alcohol Exposure and Stress​

• Collaborating with other center projects to incorporate effects of stressful life events.​
• Distinguishing the impact of chronic stress versus prenatal ethanol exposure on brain development in adolescents with FASD.​

Structural Connectivity Studies​

• Continuing research on prenatal alcohol exposure effects on structural connectivity, focusing on cortico-thalamic pathways.