Dr. Arup Das Lab

Our Research

The focus of my laboratory is on the molecular mechanisms that play an important role in the pathogenesis and development of different phenotypes of human diabetic retinopathy. By combining whole exome sequencing studies and well harmonized phenotypic analyses of patients and appropriate controls, we are studying a complex disease like diabetic retinopathy. Using cell cultures and animal models, we plan to develop gene regulatory pathways and networks by retinal cell type s, vascular and non-vascular, that will lead to novel therapeutic strategies for treatment of diabetic retinopathy. Our goal is to identify novel genetic variants and proteins for understanding the genetic mechanisms of diabetic retinopathy, and help in development of novel biomarkers, improved therapeutics and precision medicine.

Clinical Trials

As a clinical investigator, I have been involved in participating in clinical trials like EDIC (Epidemiology of Diabetes Intervention and Complications), analyzing its results and involved in writing of study results as a member of the Writing Committee of EDIC. This work has emphatically shown the importance of tight blood glucose control in slowing the progression of diabetic retinopathy. Intensive insulin therapy reduces the long-term risk of ocular surgery in patients with type 1 diabetes. We have also participated in many clinical trials with pharmacologic approaches in diabetic retinopathy (READ-2, RIDE/RISE, DRCR Protocol T, BOULEVARD, YOSEMITE).