Publications

A Full list of my published peer-reviewed work can be found on the following publically available URL

http://www.ncbi.nlm.nih.gov/sites/myncbi/erin.milligan.1/bibliography/40682877/public/?sort=date&direction=descending

Noor S, Sanchez JJ, Sun MS, Pervin Z, Sanchez JE, Havard MA, Epler LT, Nysus MV, Norenberg JP, Wagner CR, Davies S, Wagner JL, Savage DD, Jantzie LL, Mellios N, Milligan ED. The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions. Brain Behav Immun. 2020 Jul;87:339-358. doi: 10.1016/j.bbi.2020.01.002. Epub 2020 Jan 7. PubMed PMID: 31918004; PubMed Central PMCID: PMC7316595.
Yellowhair TR, Newville JC, Noor S, Maxwell JR, Milligan ED, Robinson S, Jantzie LL. CXCR2 Blockade Mitigates Neural Cell Injury Following Preclinical Chorioamnionitis. Front Physiol. 2019;10:324. doi: 10.3389/fphys.2019.00324. eCollection 2019. PubMed PMID: 31001130; PubMed Central PMCID: PMC6454349.
Yellowhair TR, Noor S, Mares B, Jose C, Newville JC, Maxwell JR, Northington FJ, Milligan ED, Robinson S, Jantzie LL.Chorioamnionitis in Rats Precipitates Extended Postnatal Inflammatory Lymphocyte Hyperreactivity. Dev Neurosci. 2019 Mar 28;:1-11. doi: 10.1159/000497273. [Epub ahead of print] PubMed PMID: 30921800; PubMed Central PMCID: PMC6765467.
Noor S, Milligan ED. Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function. Front Immunol.2018;9:1107. doi: 10.3389/fimmu.2018.01107. eCollection 2018. Review. PubMed PMID: 29910801; PubMed Central PMCID: PMC5992426.
Tyler CR, Noor S, Young TL, Rivero V, Sanchez B, Lucas S, Caldwell KK, Milligan ED, Campen MJ. Aging Exacerbates Neuroinflammatory Outcomes Induced by Acute Ozone Exposure. Toxicol Sci. 2018 May 1;163(1):123-139. doi: 10.1093/toxsci/kfy014. PubMed PMID: 29385576; PubMed Central PMCID: PMC5920500.
Vanderwall AG, Noor S, Sun MS, Sanchez JE, Yang XO, Jantzie LL, Mellios N, Milligan ED. Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues. Brain Behav Immun. 2018 Mar;69:91-112. doi: 10.1016/j.bbi.2017.11.004. Epub 2017 Nov 4. PubMed PMID: 29113923; PubMed Central PMCID: PMC5857419.
Noor S, Sanchez JJ, Vanderwall AG, Sun MS, Maxwell JR, Davies S, Jantzie LL, Petersen TR, Savage DD, Milligan ED.Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels. Brain Behav Immun. 2017 Mar;61:80-95. doi: 10.1016/j.bbi.2016.12.016. Epub 2016 Dec 20. PubMed PMID: 28011263; PubMed Central PMCID: PMC5316367.
Whitehead RA, Lam NL, Sun MS, Sanchez J, Noor S, Vanderwall AG, Petersen TR, Martin HB, Milligan ED. Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia. Anesth Analg. 2017 Jan;124(1):346-355. doi: 10.1213/ANE.0000000000001662. PubMed PMID: 27782944; PubMed Central PMCID: PMC5161547.
Dengler EC, Alberti LA, Bowman BN, Kerwin AA, Wilkerson JL, Moezzi DR, Limanovich E, Wallace JA, Milligan ED.Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain. J Neuroinflammation. 2014 May 21;11:92. doi: 10.1186/1742-2094-11-92. PubMed PMID: 24884664; PubMed Central PMCID: PMC4046049.
Milligan ED. Basic Mechanisms of Pain . In: Encyclopedia of Neurological Sciences. 2nd ed. Hayek S, editor. Oxford: Elsevier; 2014.
Dengler EC, Liu J, Kerwin A, Torres S, Olcott CM, Bowman BN, Armijo L, Gentry K, Wilkerson J, Wallace J, Jiang X, Carnes EC, Brinker CJ, Milligan ED. Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord. J Control Release. 2013 Jun 10;168(2):209-24. doi: 10.1016/j.jconrel.2013.03.009. Epub 2013 Mar 18. PubMed PMID: 23517784; PubMed Central PMCID: PMC4013798.
Watkins LR, Milligan ED, Maier SF. Neuropathic Pain Model, Neuritis/Inflammatory Neuropathy . In: Encyclopedia of Pain.2nd ed. Schmidt RF, Gebhart GF, editors. Berlin Heidelberg: Springer-Verlag; 2013.
Milligan ED, Penzkover KR, Soderquist RG, Mahoney MJ. Spinal interleukin-10 therapy to treat peripheral neuropathic pain.Neuromodulation. 2012 Nov-Dec;15(6):520-6; discussion 526. doi: 10.1111/j.1525-1403.2012.00462.x. Epub 2012 Jun 1. Review. PubMed PMID: 22672183; PubMed Central PMCID: PMC3443506.
Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Armijo LM, Kuhn MN, Thakur GA, Makriyannis A, Milligan ED.Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain.2012 May;153(5):1091-106. doi: 10.1016/j.pain.2012.02.015. Epub 2012 Mar 17. PubMed PMID: 22425445; PubMed Central PMCID: PMC3603341.
Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Kuhn MN, Zvonok AM, Thakur GA, Makriyannis A, Milligan ED.Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia. Brain Behav. 2012 Mar;2(2):155-77. doi: 10.1002/brb3.44. PubMed PMID: 22574283; PubMed Central PMCID: PMC3345359.
Wilkerson JL, Milligan ED. The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief. ISRN Anesthesiol. 2011;2011(2011). doi: 10.5402/2011/593894. PubMed PMID: 22442754; PubMed Central PMCID: PMC3308900.
Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ. PEGylation of interleukin-10 for the mitigation of enhanced pain states. J Biomed Mater Res A. 2010 Jun 1;93(3):1169-79. doi: 10.1002/jbm.a.32611. PubMed PMID: 19768789; PubMed Central PMCID: PMC3604983.
Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ. Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration. Pharm Res. 2010 May;27(5):841-54. doi: 10.1007/s11095-010-0077-y. Epub 2010 Mar 12. PubMed PMID: 20224990; PubMed Central PMCID: PMC3583569.
Soderquist RG, Milligan ED, Sloane EM, Harrison JA, Douvas KK, Potter JM, Hughes TS, Chavez RA, Johnson K, Watkins LR, Mahoney MJ. PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution. J Biomed Mater Res A. 2009 Dec;91(3):719-29. doi: 10.1002/jbm.a.32254. PubMed PMID: 19048635; PubMed Central PMCID: PMC3990442.
Loram LC, Harrison JA, Sloane EM, Hutchinson MR, Sholar P, Taylor FR, Berkelhammer D, Coats BD, Poole S, Milligan ED, Maier SF, Rieger J, Watkins LR. Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. J Neurosci. 2009 Nov 4;29(44):14015-25. doi: 10.1523/JNEUROSCI.3447-09.2009. PubMed PMID: 19890011; PubMed Central PMCID: PMC2799253.
Sloane E, Langer S, Jekich B, Mahoney J, Hughes T, Frank M, Seibert W, Huberty G, Coats B, Harrison J, Klinman D, Poole S, Maier S, Johnson K, Chavez R, Watkins LR, Leinwand L, Milligan E. Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain. Gene Ther. 2009 Oct;16(10):1210-22. doi: 10.1038/gt.2009.79. Epub 2009 Jul 2. PubMed PMID: 19571887; PubMed Central PMCID: PMC2762489.
Hughes TS, Langer SJ, Virtanen SI, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression. J Gene Med. 2009 Sep;11(9):782-90. doi: 10.1002/jgm.1364. PubMed PMID: 19533588; PubMed Central PMCID: PMC3649870.
Sloane EM, Soderquist RG, Maier SF, Mahoney MJ, Watkins LR, Milligan ED. Long-term control of neuropathic pain in a non-viral gene therapy paradigm. Gene Ther. 2009 Apr;16(4):470-5. doi: 10.1038/gt.2009.21. Epub 2009 Mar 5. Review. PubMed PMID: 19262611; PubMed Central PMCID: PMC2756299.
Sloane E, Ledeboer A, Seibert W, Coats B, van Strien M, Maier SF, Johnson KW, Chavez R, Watkins LR, Leinwand L, Milligan ED, Van Dam AM. Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy. Brain Behav Immun. 2009 Jan;23(1):92-100. doi: 10.1016/j.bbi.2008.09.004. Epub 2008 Sep 20. PubMed PMID: 18835435; PubMed Central PMCID: PMC2631931.
Milligan ED, Soderquist RG, Mahoney MJ. Gene therapy via spinal neuroimmune interactions: new targets for clinical pain control . In: Synaptic Plasticity in Pain. Malgangio M, editor. NY: Springe; 2009. p.367-386.
Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci. 2009 Jan;10(1):23-36. doi: 10.1038/nrn2533. Review. PubMed PMID: 19096368; PubMed Central PMCID: PMC2752436.
Milligan ED, Maier SF, Watkins LR. Gene Therapy in Central Nervous System . In: Encyclopedia of Neuroscience. Windhorst U, Binder M, Hirokawa N, editors. Berlin Heidelberg: Springer-Verlag; 2009.
Hughes TS, Langer SJ, Johnson KW, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins. Mol Ther. 2009 Jan;17(1):88-94. doi: 10.1038/mt.2008.230. Epub 2008 Oct 21. PubMed PMID: 18941439; PubMed Central PMCID: PMC2834984.
Miller RJ, Rostene W, Apartis E, Banisadr G, Biber K, Milligan ED, White FA, Zhang J. Chemokine action in the nervous system. J Neurosci. 2008 Nov 12;28(46):11792-5. doi: 10.1523/JNEUROSCI.3588-08.2008. Review. PubMed PMID: 19005041; PubMed Central PMCID: PMC2746239.
Milligan ED, Sloane EM, Watkins LR. Glia in pathological pain: a role for fractalkine. J Neuroimmunol. 2008 Jul 31;198(1-2):113-20. doi: 10.1016/j.jneuroim.2008.04.011. Epub 2008 Jun 10. Review. PubMed PMID: 18547654; PubMed Central PMCID: PMC3289257.
Ashton JC, Milligan ED. Cannabinoids for the treatment of neuropathic pain: clinical evidence. Curr Opin Investig Drugs.2008 Jan;9(1):65-75. Review. PubMed PMID: 18183533.
Watkins LR, Milligan ED, Maier SF. Mechanisms of glial activation after nerve injury . In: The Senses: A Comprehensive Reference. Vol 5 ed. Bushnell C, Basbaum A, editors. Oxford: Elsevier Press; 2008. p.429-433.
Watkins LR, Hutchinson MR, Milligan ED, Maier SF. "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev. 2007 Nov;56(1):148-69. doi: 10.1016/j.brainresrev.2007.06.006. Epub 2007 Jul 13. Review. PubMed PMID: 17706291; PubMed Central PMCID: PMC2245863.
Schoeniger-Skinner DK, Ledeboer A, Frank MG, Milligan ED, Poole S, Martin D, Maier SF, Watkins LR. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain Behav Immun. 2007 Jul;21(5):660-7. doi: 10.1016/j.bbi.2006.10.010. Epub 2007 Jan 3. PubMed PMID: 17204394; PubMed Central PMCID: PMC1991283.
Ledeboer A, Jekich BM, Sloane EM, Mahoney JH, Langer SJ, Milligan ED, Martin D, Maier SF, Johnson KW, Leinwand LA, Chavez RA, Watkins LR. Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun. 2007 Jul;21(5):686-98. doi: 10.1016/j.bbi.2006.10.012. Epub 2006 Dec 15. PubMed PMID: 17174526; PubMed Central PMCID: PMC2063454.
Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun. 2007 Feb;21(2):131-46. doi: 10.1016/j.bbi.2006.10.011. Epub 2006 Dec 18. PubMed PMID: 17175134; PubMed Central PMCID: PMC1857294.
Milligan ED, Ledeboer A, Sloane EM, Watkins LR. Glially driven enhancement of pain and its control by anti-inflammatory cytokines . In: Immune and Glial Regulation of Pain. Watkins LR, DeLeo J, Sorkin L, editors. Seattle: IASP Press; 2007. p.319-337.
Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, Watkins LR. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 2006 Dec 15;126(1-3):294-308. doi: 10.1016/j.pain.2006.07.009. Epub 2006 Sep 1. PubMed PMID: 16949747.
Milligan ED, Soderquist RG, Malone SM, Mahoney JH, Hughes TS, Langer SJ, Sloane EM, Maier SF, Leinwand LA, Watkins LR, Mahoney MJ. Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol. 2006 Nov;2(4):293-308. doi: 10.1017/S1740925X07000488. PubMed PMID: 18079973; PubMed Central PMCID: PMC2133369.
Ledeboer A, Mahoney JH, Milligan ED, Martin D, Maier SF, Watkins LR. Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats. J Pain. 2006 Oct;7(10):757-67. doi: 10.1016/j.jpain.2006.04.001. PubMed PMID: 17018336.
Watkins LR, Wieseler-Frank J, Milligan ED, Johnston I, Maier SF. Chapter 22 Contribution of glia to pain processing in health and disease. Handb Clin Neurol. 2006;81:309-23. doi: 10.1016/S0072-9752(06)80026-6. PubMed PMID: 18808844.
Milligan E, Zapata V, Schoeniger D, Chacur M, Green P, Poole S, Martin D, Maier SF, Watkins LR. An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Eur J Neurosci. 2005 Dec;22(11):2775-82. doi: 10.1111/j.1460-9568.2005.04470.x. PubMed PMID: 16324111.
Beutler AS, Banck MS, Walsh CE, Milligan ED. Intrathecal gene transfer by adeno-associated virus for pain. Curr Opin Mol Ther. 2005 Oct;7(5):431-9. Review. PubMed PMID: 16248278.
Ledeboer A, Sloane EM, Milligan ED, Frank MG, Mahony JH, Maier SF, Watkins LR. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain. 2005 May;115(1-2):71-83. doi: 10.1016/j.pain.2005.02.009. PubMed PMID: 15836971.
Milligan ED, Langer SJ, Sloane EM, He L, Wieseler-Frank J, O'Connor K, Martin D, Forsayeth JR, Maier SF, Johnson K, Chavez RA, Leinwand LA, Watkins LR. Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci. 2005 Apr;21(8):2136-48. doi: 10.1111/j.1460-9568.2005.04057.x. PubMed PMID: 15869510.
Twining CM, Sloane EM, Schoeniger DK, Milligan ED, Martin D, Marsh H, Maier SF, Watkins LR. Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization. J Pain. 2005 Mar;6(3):174-83. doi: 10.1016/j.jpain.2004.11.011. PubMed PMID: 15772911.
Milligan ED, Sloane EM, Langer SJ, Cruz PE, Chacur M, Spataro L, Wieseler-Frank J, Hammack SE, Maier SF, Flotte TR, Forsayeth JR, Leinwand LA, Chavez R, Watkins LR. Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain. 2005 Feb 25;1:9. doi: 10.1186/1744-8069-1-9. PubMed PMID: 15813997; PubMed Central PMCID: PMC1079940.
Watkins LR, Wieseler-Frank J, Milligan ED, Johnston I, Maier SF. Contribution of glia to pain processing in health and disease . In: Handbook of Clinical Neurology. Vol 81 ed. Cervero F, Jensen TS, editors. Oxford: Elsevier; 2005. p.309-323.
Milligan ED, Zapata V, Chacur M, Schoeniger D, Biedenkapp J, O'Connor KA, Verge GM, Chapman G, Green P, Foster AC, Naeve GS, Maier SF, Watkins LR. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Eur J Neurosci. 2004 Nov;20(9):2294-302. doi: 10.1111/j.1460-9568.2004.03709.x. PubMed PMID: 15525271.
Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci. 2004 Sep;20(5):1150-60. doi: 10.1111/j.1460-9568.2004.03593.x. PubMed PMID: 15341587
Chacur M, Gutiérrez JM, Milligan ED, Wieseler-Frank J, Britto LR, Maier SF, Watkins LR, Cury Y. Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators. Pain. 2004 Sep;111(1-2):65-76. doi: 10.1016/j.pain.2004.06.001. PubMed PMID: 15327810.
Spataro LE, Sloane EM, Milligan ED, Wieseler-Frank J, Schoeniger D, Jekich BM, Barrientos RM, Maier SF, Watkins LR. Spinal gap junctions: potential involvement in pain facilitation. J Pain. 2004 Sep;5(7):392-405. doi: 10.1016/j.jpain.2004.06.006. PubMed PMID: 15501197.
Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci. 2004 Aug 18;24(33):7353-65. doi: 10.1523/JNEUROSCI.1850-04.2004. PubMed PMID: 15317861; PubMed Central PMCID: PMC6729781.
Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS). Pain. 2004 Aug;110(3):517-30. doi: 10.1016/j.pain.2004.02.018. PubMed PMID: 15288392.
Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, Poole S, Marsh H, Maier SF, Watkins LR. Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain.2004 Jul;110(1-2):299-309. doi: 10.1016/j.pain.2004.04.008. PubMed PMID: 15275780.
Chacur M, Milligan ED, Sloan EM, Wieseler-Frank J, Barrientos RM, Martin D, Poole S, Lomonte B, Gutiérrez JM, Maier SF, Cury Y, Watkins LR. Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide. Pain. 2004 Mar;108(1-2):180-91. doi: 10.1016/j.pain.2003.12.023. PubMed PMID: 15109522.
Milligan ED, Maier SF, Watkins LR. Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing. Methods Mol Med. 2004;99:67-89. doi: 10.1385/1-59259-770-X:067. PubMed PMID: 15131330.
Milligan ED, Maier SF, Watkins LR. Sciatic inflammatory neuropathy: a new model for studying neuropathic pain of inflammatory origin . In: Methods of Molecular Medicine. Vol 99 ed. Luo D, editor. Totowa, NJ USA: Humana Press; 2004. 303p.
O'Connor KA, Hansen MK, Rachal Pugh C, Deak MM, Biedenkapp JC, Milligan ED, Johnson JD, Wang H, Maier SF, Tracey KJ, Watkins LR. Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine. 2003 Dec 21;24(6):254-65. doi: 10.1016/j.cyto.2003.08.001. PubMed PMID: 14609567.
Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S, Tracey K, Martin D, Maier SF, Watkins LR. Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci. 2003 Feb 1;23(3):1026-40. PubMed PMID: 12574433; PubMed Central PMCID: PMC6741915.
Milligan ED, O'Connor KA, Armstrong CB, Hansen MK, Martin D, Tracey KJ, Maier SF, Watkins LR. Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats. J Pain. 2001 Dec;2(6):326-33. doi: 10.1054/jpai.2001.26174. PubMed PMID: 14622812.
Chacur M, Milligan ED, Gazda LS, Armstrong C, Wang H, Tracey KJ, Maier SF, Watkins LR. A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats. Pain. 2001 Dec;94(3):231-44. doi: 10.1016/s0304-3959(01)00354-2. PubMed PMID: 11731060.
Gazda LS, Milligan ED, Hansen MK, Twining CM, Poulos NM, Chacur M, O'Connor KA, Armstrong C, Maier SF, Watkins LR, Myers RR. Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production. J Peripher Nerv Syst. 2001 Sep;6(3):111-29. doi: 10.1046/j.1529-8027.2001.006001111.x. PubMed PMID: 11817330.
Watkins LR, Milligan ED, Maier SF. Spinal cord glia: new players in pain. Pain. 2001 Sep;93(3):201-5. doi: 10.1016/s0304-3959(01)00359-1. Review. PubMed PMID: 11514078.
Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci. 2001 Aug;24(8):450-5. doi: 10.1016/s0166-2236(00)01854-3. Review. PubMed PMID: 11476884.
Milligan ED, O'Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, Watkins LR.Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci. 2001 Apr 15;21(8):2808-19. PubMed PMID: 11306633; PubMed Central PMCID: PMC6762530.
Milligan ED, Mehmert KK, Hinde JL, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR. Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res. 2000 Apr 7;861(1):105-16. doi: 10.1016/s0006-8993(00)02050-3. PubMed PMID: 10751570.
Akana SF, Strack AM, Hanson ES, Horsley CJ, Milligan ED, Bhatnagar S, Dallman MF. Interactions among chronic cold, corticosterone and puberty on energy intake and deposition. Stress. 1999 Dec;3(2):131-46. doi: 10.3109/10253899909001118. PubMed PMID: 10938575.
Milligan ED, Hinde JL, Mehmert KK, Maier SF, Watkins LR. A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats. J Neurosci Methods. 1999 Aug 1;90(1):81-6. doi: 10.1016/s0165-0270(99)00075-8. PubMed PMID: 10517276.
Maier SF, Nguyen KT, Deak T, Milligan ED, Watkins LR. Stress, learned helplessness, and brain interleukin-1 beta. Adv Exp Med Biol. 1999;461:235-49. doi: 10.1007/978-0-585-37970-8_13. Review. PubMed PMID: 10442176.
Milligan ED, McGorry MM, Fleshner M, Gaykema RP, Goehler LE, Watkins LR, Maier SF. Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication. Brain Res. 1997 Aug 22;766(1-2):240-3. doi: 10.1016/s0006-8993(97)00705-1. PubMed PMID: 9359608.
Akana SF, Hanson ES, Horsley CJ, Strack AM, Bhatnagar S, Bradbury MJ, Milligan ED, Dallman MF. Clamped Corticosterone (B) Reveals the Effect of Endogenous B on Both Facilitated Responsivity to Acute Restraint and Metabolic Responses to Chronic Stress. Stress. 1996 Jul;1(1):33-49. doi: 10.3109/10253899609001094. PubMed PMID: 9807060.