Domenici Hall's cutting-edge and centralized research cores provide an array of services dedicated to furthering brain research.
The cores are open to all scientists interested in using neuroimaging tools to discover the mechanisms of brain functions in health and disease. We welcome brain and behavioral health scientists from University of New Mexico and beyond to join our exciting international research environment.
The Clinical Core is a fundamental component of the Center for Brain Recovery and Repair (CBRR) established by an NIGMS Center for Biomedical Research Excellence (CoBRE) grant.
The Clinical Core is located in Domenici Hall on UNM’s North Campus strategically located in the very heart of the UNM neuroscience research community. This core provides facilities, resources and expertise to support clinical neuroscience investigations.
It includes a neuropsychological assessment library, clinical research assessment rooms, cutting-edge technology (e.g., tDCS, EEG), well-trained research assistants/psychometrists, as well as training to support the design and implementation of clinical neuroscience investigations.
The Clinical Core provides a convenient, participant-friendly point-of-service, adjacent to basic research, neuroimaging, and clinical medicine facilities.
| Service | Description | UNM Investigator Rate | Non-UNM Rate |
| Research Assistant/Technician | RA for recruitment, study development, study support, administration, scoring, data management/analysis | $30/hour | $40/hour |
|---|---|---|---|
| Room use | Applies to use of core testing rooms (rooms 1035 or 1037). Must be returned to “pre-visit” appearance. | $15/hour | $30/hour |
| Neuropsychological Test Library use only | Includes use of core neuropsychological tests and protocols off-site; no core research assistant provided | $10/hour | $30/hour |
| Neuropsychological Test Library with core room use without core research assistant | Includes use of core space and neuropsychological test materials (i.e., manuals, kits, etc.), use of laptop computer for test administration, questionnaires; User provides trained research assistant to conduct session * | $25/hour | $60/hour |
| Neuropsychological Test Library with core room use and core research assistant | Includes use of core space and neuropsychological test materials (i.e., manuals, kits, etc.), use of laptop computer for test administration, questionnaires, and test administration with core research assistant to conduct session | $55/hour | $90/hour |
| EEG only | Includes EEG equipment use off-site without core research assistant* | $50/hour | $100/hour |
| EEG with core room use without core research assistant | Includes use of core space and EEG equipment/supplies; User provides trained research assistant to conduct session * | $65/hour | $130/hour |
| EEG with core room use and core research assistant | Includes use of core space and EEG equipment, supplies tDCS w/supplies, EEG w/supplies with core research assistant. | $95/hour | $160/hour |
| EEG Analysis | Includes use of Neurofax platform; BrainVision Analyzer | $15/hour | $30/hour |
| HD tDCS equipment use only | Includes use of core HD tDCS equipment without core research assistant; user provides trained research assistant to conduct session * | $50/hour | $100/hour |
| HD tDCS with core room use without core research assistant | Includes core room use + core HD tDCS equipment use; User provides research assistant to conduct session * | $65/hour | $130/hour |
| HD tDCS with core room use and core research assistant | Includes core room use + core HD tDCS equipment use and core research assistant to conduct session | $95/hour | $160/hour |
| fNIRS only | Includes use of core fNIRS equipment; user provides trained research assistant to conduct session * | $50/hour | $100/hour |
| fNIRS core room use + fNIRS equipment without research assistant | Includes core space, fNIRS equipment/supplies. User provides own research assistant to conduct session * | $65/hour | $130/hour |
| fNIRS with Core room use and core research assistant | Includes use of core space, fNIRS equipment/supplies, and core research assistant to conduct session | $95/hour | $160/hour |
| Training for use of core resources | Training in test administration/scoring of neuropsychological measures, use of EEG, tDCS or fNIRS equipment | $20/hour | $40/hour |
| Consultation | Includes time for guidance on research design | No charge | $50/hour |
Our core facilities scheduling is ran through iLabs. If you or your student needs an iLabs account to use our facilities, please contact the Clinical Research Supervisor, Darbi Gill, to have an MOU created, and an iLabs account set up for use.
The Pre-Clinical Core Facility houses resources for automated behavioral testing, including touchscreen inputs and gait analysis tools.
The resources at the Pre-Clinical Core include automated animal tracking systems, learning and memory tasks, motor and gait analysis systems, in-vivo single and multiphoton imaging, optogentics, in-vivo electrophysiology, histology, and 3D and 4D image analysis.
| Service | Details | UNM-Affiliated Research | Non-UNM or Industry Research |
|---|---|---|---|
| Training and Consultations | All users must be trained on the equipment prior to use of the facilities. The Pre-Clinical Core Staff can also provide consultations for experimental design and troubleshooting. | $40.00/hour | $50.00/hour |
| Project Development | Individualized assistance to investigators to develop detailed protocols, experimental design, or assist with data interpretation |
$40.00/hour | $50.00/hour |
| Behavior | |||
| Ethovision Motion Tracking | Includes: open field, novel object recognition, Y-maze, zero maze, and Morris water maze. |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
| Fear Conditioning | Trace and/or contextual fear conditioning |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
| Rotarod | Simple and effective way to measure motor learning. |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
| Touchscreen | Touchscreen based cognitive tasks |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
| Home Cage Monitoring | For precise montioring, recording, and analysis of movement |
$8.00/day (usage fee) |
$12.00/day (usage fee) |
| Catwalk | A sophisticated and high-through put system to measure gate and motor performance in mice or rats. |
$20/hour (service) $10/hour (usage) |
$30/hour (service) $15/hour (usage) |
| Microscopy | |||
| Epi-Fluorescence Microscopy |
The Preclinical offers a single photon epi-fluorecence microscope |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
| In-vivo electrophysiology, optogenetics | Highly effective ways to manipulate neuronal activity while the animal is awake and behaving. |
$25/hour (service) $12.50/hour (usage) |
$38/hour (service) $20/hour (usage) |
| In-vivo mini-scopes | An innovative way to visually monitor neuronal activity in awake and behaving animals. |
$25/hour (service) $12.50/hour (usage) |
$38/hour (service) $20/hour (usage) Data |
| CLARITY | An innovative way to optically clear tissue to image large fluorescent 3 dimensional structures. |
$300 for first sample, $200 for each additional sample (service) $10 for first sample, $5 for each additional sample (usage) |
$450.00 for the first sample, $300.00 for each additional sample (service) $15.00 for the first sample, $7.50 for each additional sample (usage) |
| Imaris 3D and 4D image analysis software | Highly powerful analysis software capable of automated 3D and 4D quantification. |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
| Anesthetized two photon-imaging | High resolution in-vivo imaging of vascular network, neuronal morphology, and network activity. | $40/hour | $80/hour |
| Till Photonic Fluorescence Imaging system | High Speed fluorescence Ca2+ imaging of in-vitro cultures, ex-vivo tissue, or anesthetized in-vivo. | $15/hour | $55/hour |
| Laser Speckle Contrast Imaging (LSCI) system | Macroscopic laser based imaging system that monitors and measures blood flow | $15/hour | $55/hour |
| Slice Electrophysiology combined with Till Photonics fluorescence imaging system | Slice electrophysiology in combination with simultaneous high speed fluorescence Ca2+ imaging | $15/hour | $55/hour |
| Histology | |||
| Tissue Processing (Sliding Knife, Vibrating microtome, or Cryostat) | The Pre-Clinical offers a variety of tissue processing methods suitable for a variety of histological protocols. |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
| Immunohistochemistry | The Preclinical offers a variety of Immunohistochemistry and histological stains. |
$15.50/hour (service) $7.50/hour (usage) |
$25/hour (service) $12/hour (usage) |
Our core facility scheduling utilizes iLabs management software. Please contact the Pre-Clinical Core Manager, Carissa Milliken for MOU and iLabs account set up.
The Preclinical Imaging Core includes an actively shielded 7.0T MRI scanner (Bruker BioSpin) dedicated exclusively to animal imaging.
The Preclinical Imaging Core is capable of several types of imaging:
The Preclinical Imaging Core houses a 7.0T 40 cm bore MR scanner for both structural and functional MRI in animal models. This actively shielded Bruker NMRI system is equipped with two distinct water-cooled gradient sets:
Both gradient sets can tolerate the high duty cycles required for fast imaging techniques like Echo Planar Imaging (EPI).
The NMRI system is equipped with Bruker AVANCE I electronics located in a separate room adjacent to the magnet. The AVANCE system consists of waveform generation, receiver, and digitizer units, and a 64-bit CPU for data pre-processing.
The Preclinical Imaging Core can provide access to a variety of coils. All coils are compatible with fast imaging methods (EPI, DTI, and fMRI).
A dedicated workstation is available for data transfer and offline data processing.
The Preclinical Imaging Core is well equipped for animal handling.
| UNM-Affiliated Research | Non-UNM or Industry Research | |
|---|---|---|
| Preclinical Imaging Core Resource Use | $150 | $300 |
