Diane S. Lidke's research focuses on the application of fluorescence microscopy and biophysical techniques to the study of cell signal transduction. The theme of Dr. Lidke's work is to visualize and quantify protein dynamics that regulate cell signaling, both in the normal and diseased state. The ultimate goal is to identify the molecular mechanisms that alter signaling in cancer and the immune response.
Research in the Lidke Laboratory integrates the disciplines of biophysics, bio-imaging and quantitative biology to gain new and fundamental understanding of the components and dynamics of cell signaling pathways. This involves the measurement of protein behavior in living cells to capture and quantify biochemical events that initiate signaling. The focus is on the study of the receptor tyrosine kinases and immunoreceptors, and how these are altered in disease or influenced by therapeutics.
Diane Lidke, Ph.D.
Professor & Vice-Chair for Research, Department of Pathology
Lidke received her B.S. degree in Physics in 1994. She earned her PhD in Biophysical Sciences & Medical Physics from the University of Minnesota in 2002. Her postdoctoral research was in the lab of Thomas Jovin at the Max Planck Institute for Biophysical Chemistry in Goettingen, Germany. She joined the UNM Pathology Department in 2005.
N.L. Andrews, J.R. Pfeiffer, A.M. Martinez, D.M. Haaland, R.W. Davis, T. Kawakami, J.M. Oliver, B.S. Wilson and D.S. Lidke. Small, mobile FcRI aggregates are signaling competent. Immunity, 31: 469-479 (2009) PMC2828771
S.T. Low-Nam, K.A. Lidke, P.J. Cutler, R.C. Roovers, P.M.P. van Bergen en Henegouwen, B.S. Wilson, D.S. Lidke. ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand. Nature Structural & Molecular Biology, 18: 1244-1249 (2011) PMC3210321
S.L. Schwartz, C. Cleyrat, M. Olah, P. Relich, G. Phillips, W.S. Hlavacek, K.A. Lidke, B.S. Wilson and D.S. Lidke. Differential mast cell outcomes are sensitive to FcRI-Syk binding kinetics. Molecular Biology of the Cell - Quantitative Biology Special Issue 28: 3397-3414 (2017) PMC5687039**MBoC Highlight article
A.M. Brandsma*, S.L. Schwartz*, C.C. Valley, G.L.A. Blezer, G. Vidarsson, K.A. Lidke, T. ten Broeke, D.S. Lidke^, J.H.W. Leusen^. Mechanisms of inside-out signaling of the high affinity IgG-receptor FcRI. Science Signaling. 11: eaaq0891 (2018) PMID: 30042128 ^Lidke and Leusen are co-corresponding authors.
E. Salazar-Cavazos, C. Franco Nitta, E.D. Mitra, B.S. Wilson, K.A. Lidke, W.S. Hlavacek, Lidke, D.S. Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes. Molecular Biology of the Cell, 19:695-708 (2020) PMC7202077
Diane S. Lidke. Ph.D.
Department of Pathology
Cancer Research Facility, Room 203
University of New Mexico School of Medicine
Albuquerque, New Mexico 87131