Poddar Lab

Research Interests

Principal Investigator Ranjana Poddar, PhD, leads this lab in their evaluation of hyperhomocysteinemia, a metabolic disorder characterized by systemic elevation of homocysteine, in the progression of age-associated neurological diseases.

Recent findings from her laboratory provides compelling evidence that predisposition to even mild hyperhomocysteinemia conditions drastically exacerbates brain damage in both rat and mice models of ischemic stroke. This adverse effect hyperhomocysteinemia on ischemic stroke involves activation of a unique signaling pathway mediated through NR2A subunit containing NMDA receptor stimulation, which is generally thought to promote neuronal survival.

Current Research

The laboratory is currently exploring:

  • Long-term pathological and behavioral outcome of ischemic insult under hyperhomocysteinemic condition
  • Signaling mechanisms involved in hyperhomocysteinemia-induced exacerbation of ischemic injury
  • Potential therapeutic targets to minimize the severity of ischemic brain damage under hyperhomocysteinemic conditions

Additional Research

Dr. Poddar’s laboratory is also interested in understanding the pathological consequences of vascular dementia under hyperhomocysteinemic conditions. These projects utilize rodent models of ischemic stroke (middle cerebral artery occlusion) and hyperhomocysteinemia, genetic mice models of dementia, transgenic and knockout mice, magnetic resonance imaging, behavioral studies, tissue culture, pharmacology, molecular biology, biochemistry, microscopy and flow-cytometry.