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August 28, 2022: Satellite Meeting for Trainees (Day 0)
La Fonda Hotel, Santa Fe, New Mexico, August 28th, 2022
Open to all registered trainees (postdoctoral fellows, graduate students, undergraduate students)
Please contact the IPTC organizing committee at 2022IPTC@salud.unm.edu by August 15th to confirm attendance (and lunch).
8:30 - Convene, Registration
8:45 - Welcome, Opening Remarks - Alexandra Noël, PhD, LSU
9:00 - The road traveled to predicting potential human health effects of carbon nanotubes & nanofibers - Aaron Erdely, PhD, NIOSH
9:30 - Training/Workshop: Computational modeling for inhaled aerosols - Annie Jarabek, US EPA
10:45 - Coffee Break
11:00 - Inhaled Aerosol Practicum: Application of the EPA MPPD Model for Interspecies Extrapolation and Risk Assessment: A Tale of Two Use Cases - Trainees’ activity
12:45 - Lunch
1:45 - Career Oriented Talk (20 min) + Q & A with trainees - Academia (10 min) - Phoebe Stapleton, PhD, Rutgers University
2:15 - Career Oriented Talk (20 min) + Q & A with trainees - Government (10 min) - Aaron Erdely, PhD, NIOSH
2:45 - Coffee Break
Trainees’ platform presentations
3:00 - Role of Lipid Metabolism in Particulate Matter - Induced Lung Inflammation and Injury (10 min) - Hannah Lovins, OSU
3:15 - Particulate Air Pollution and Viral Activation by Airway Proteases: Assessed by a Novel Assay in Human Nasal Epithelial Cells (10 min) - Stephanie Brocke, UNC
3:45 - Physicochemical Drivers of Primary Toxicologic Outcomes induced by Carbon Nanotubes and Nanofibers from U.S. Facilities (10 min) - Kelly Fraser, NIOSH
4:00 - Coffee Break
4:15 - Magnetic Resonance Imaging Contrast Agents Induce Acute Tubular Damage and Gadolinium-rich Nanoparticle Formation in Renal Cortex (10 min) - Joshua DeAguero, UNM
4:30 - Acrolein, a major constituent of combustion emissions, induces sexually dimorphic neuroendocrine and metabolic dysfunction (10 min) - Devin Alewel, US EPA
5:00 - Awards announcement - Matthew Campen, PhD, UNM & Alexandra Noël, PhD, LSU
5:10 - Concluding remarks, Adjournment - Alexandra Noël, PhD, LSU
August 28, 2022: Pre-Conference Workshop (Day 0)
IPTC 2022, Sante Fe
Sunday Aug 28, 4:30-6:30 pm, La Fonda hotel, Stiha Room (2nd floor)
Animal models for air pollution need new approaches to reproducibility
Caleb E Finch (USC) and Matthew J Campen (UNM), Chairs.
Open to all registered attendees
Chronic exposure to elevated air pollution particles and gases is strongly associated with diseases of arteries, brain, heart, and lungs. Corresponding experimental animal models include exposure to ambient or concentrated air pollution particles, gases, and diverse subcomponents. Extensive data indicates shared biochemical and genomic responses of air pollution associated diseases. However, experimentalists are challenged by wide variations of ambient air pollution and its components by location and time, and different sources of sub-components, like diesel exhaust particles (DEP).
Speakers:
Pamela J. Lein (UC Davis) Rodent models for exposure to traffic tunnel air pollution collected and delivered unchanged in real-time: strengths and limitations.
C. E. Finch and Kristina Shkirkova (USC): Diesel exhaust particles from NIST induce dose and time-dependent neurotoxic responses in mouse grey and white matter.
Joel Kaufman (U Washington): Freshly-generated, diluted, and aged diesel exhaust as an inhalation model for traffic-related air pollution: strengths and limitations.”
M.J. Campen: Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity.
Urmila Kodavanti (EPA): “Incorporating neuroendocrine mechanisms and resiliency in assessing air pollution health effects.”
Ralf Zimmerman (University of Rostock) “Which chemical aerosol properties shall be measured in particle toxicological studies? Novel approaches for particle characterization to complement aerosol toxicological studies”
Open discussion: Jon Samet (U Colorado), (CE Finch) and MJ Campen) Approaches to shared standards for animal exposures. Should we consider a shared air pollution particle standard, modeled after the ‘Research Cigarette’ for tobacco toxicity.
August 29, 2022 (Conference Day 1)
8:00 - Convene, Registration, Breakfast
8:40 - Welcome, Opening Remarks - Campen, Brown, Gordon
9:00 - Keynote – Comparative chemistry and toxicity of combustion emissions from biomass and synthetic materials. - Ian Gilmour, PhD, USEPA
9:40 - Research seminars: Wildfire-Related Exposures and Health Effects. - Alexandra Noël, PhD, Matthew Campen PhD, Chairs
9:40 - Pre-existent stress increases susceptibility to ozone and wildfire smoke exposure - Thomas Jackson, US Environmental Protection Agency
10:00 - Neurometabolomic Impacts of Modeled Wildfire Smoke Exposure in Aged Female C57BL/6 Mice - David Scieszka, University of New Mexico
10:20 - Repeated Exposure to Wildfire Smoke Alters Pulmonary Gene and Metabolic Profiles in Male Long-Evans Rats - Katelyn Dunigan-Russell, The Ohio State University
10:40 - Coffee Break
11:00 - Invited Speaker – Wildfire Occupational Exposures - Olorunfemi Adetona, PhD, Ohio State University
11:40 - Research seminars: Combustion-Source PM - Flemming Cassee, PhD, Chris Reilly, PhD, Chairs
11:40 - Sputum macrophage carbon load as a biomarker for episodic exposure to ambient combustion particles - Shuguang Leng, University of New Mexico
12:00 - Effect of Combustion Particle Morphology on Biological Responses in a Co-culture of Human Lung Epithelial (A549) and Macrophage-like (THP-1) Cells at Air-liquid Interface Exposure Conditions - Kamaljeet Kaur, University of Utah
12:20 - Exposure to eucalyptus smoke during sperm maturation alters motility and non-coding RNAs in caudal sperm - Colette Miller, US Environmental Protection Agency
12:40 - Inhalation toxicity of copper sulphate pentahydrate and dicopper oxide - Regulatory Compliance Limited, Edinburgh, UK
1:00 - Paper of the Year – Particle and Fibre Toxicology - Flemming Cassee, Editor in Chief
1:05 - Lunch - Provided by Hotel
2:00 - Invited Speaker – Is the placenta a barrier to microplastics? - Phoebe Stapleton, PhD, Rutgers University
2:40 - Research seminars: PM Composition and health effects. - Marcus Garcia, Pharm.D., Eliseo Castillo, PhD, Chairs
2:40 - Exposure and pulmonary toxicity assessments of dusts from machined plastic nanocomposites - Todd Stueckle, National Institute of Occupational Safety and Health, WV
3:00 - Ultrafine particulate matter exposure aggravates pulmonary response to influenza infection during pregnancy - Natalie Johnson, Texas A&M University
3:20 - Systemic Translocation of Polystyrene Microspheres: Quantitation Following Chronic Oral Gastric Exposure - Marcus Garcia, University of New Mexico
3:40 - Invited Speaker – Airborne Plastics - Alison Elder, University of Rochester
4:10 - Poster Session 1 - Posters will be arranged on the perimeter of the Lumpkins Ballroom and around the Mezzanine. They will be displayed all day, but attended from 4-6 pm for a dedicated viewing and social networking opportunity.
6:00 - Dinner – free schedule - Santa Fe is a culinary gem in the U.S. with a variety of Southwestern restaurants and other diverse options within walking distance from the hotel. We encourage attendees from near and far to enjoy their visit!
August 30, 2022 (Conference Day 2)
8:00 - Breakfast - Light breakfast will be available for attendees
9:00 - Invited Speaker – The Potential Involvement of Inhaled Iron in the Neurotoxic Effects of Ultrafine Particulate Matter Air Pollution Exposure on Brain Development in Mice - Marissa Sobolewski, Ph.D. University of Rochester
9:40 - Research seminars: Systemic Health Effects of PM. - Urmila Kodavanti, PhD, Flemming Cassee, PhD, Chairs
9:40 - A Case for Amorphous Silica Exposure in the Development of Chronic Kidney Disease of an Unknown Etiology - Keegan Rogers, University of Colorado
10:00 - Nanomaterial induced effects in the healthy vs. diseased liver - Ali Kermanizadeh, University of Derby
10:20 - Understanding the Lung - Gut Axis by Modeling the Influence of Genetic Diversity, Welding Fume Inhalation Exposure, and Lifestyle, on the Profile of Gut - Vamsi Kodali, National Institute of Occupational Safety and Health, WV
10:40 - Coffee Break
11:00 - Emulating near - roadway exposure to traffic - related air pollution via real - time emissions from a major freeway tunnel system - Keith Bein, University of California, Davis
11:20 - The effects of chronic exposure to ambient traffic-related air pollution on Alzheimer’s disease phenotypes in wildtype and genetically predisposed male and female rats - Pamela Lein, University of California, Davis
11:40 - The effects of traffic-related air pollution exposure on Alzheimer’s disease-like pathology in mice - Roel Schins, IUF-Leibniz Research Institute for Environmental Medicine
12:00 - Neurotoxic Responses to Diesel Exhaust Particle NIST 2975 - Kristina Shkirkova, University of Southern California
12:20 - Bridging the Pulmonary Toxicity of Inhaled Vapor/Liquid and Solid Particle-like Phases - Prof. Jürgen Pauluhn
12:40 - Who put gases (aldehydes) in my particles? Electronic cigarette-derived particles (and gases) in cardiovascular and pulmonary toxicity - Daniel Conklin, University of Louisville
1:00 - Lunch - Provided by Hotel
2:00 - Invited Speaker – Evidence Integration for Risk Assessment of Inhaled Aerosols: Coupling Complimentary Experimental Work and Computational Workflows to Advance an Inhalation Integrated Approach to Testing and Assessment (iIATA) - Annie Jarabek, USEPA
2:40 - Research seminars: Emerging Science, Novel Approaches - Aaron Erdely, PhD and Terry Gordon, PhD, Chairs
2:40 - Lipid Mediated Exacerbation of Nanoparticle-Induced Pulmonary Inflammation - Jonathan Shannahan, Purdue University
3:00 - Cholesterol and particle-induced lysosomal membrane permeability - Rebekah Kendall, University of Montana
3:20 - Serum Peptidome: Diagnostic Window into Pathogenic Processes following Occupational Exposure to Carbon Nanomaterials - Andrew Ottens, Virginia Commonwealth University
3:40 - Invited Speaker – Nanoparticle modulation of pulmonary immune responses to inhaled allergens - Jamie Bonner, North Carolina State University
4:10 - Poster Session 2 - Posters will be arranged on the perimeter of the Lumpkins Ballroom and around the Mezzanine. They will be displayed all day, but attended from 4-6pm for a dedicated viewing and social networking opportunity.
6:00 - Dinner – La Terraza - Southwestern-themed dinner for all attendees will be provided in the indoor-outdoor La Terraza facility at the La Fonda Hotel
August 31, 2022 (Conference Day 3)
8:00 - Reconvene, Introduction of Speaker - Jared Brown, PhD
8:20 - Keynote – A Panorama of Airborne Particles: From Then to Now and From Local to Global - Jon Samet, MD, University of Colorado School of Public Health
9:00 - Research seminars. Global PM Issues - Jared Brown, PhD and Roel Schins, PhD, Chairs
9:00 - Endotoxin exacerbates the NLRP3- dependent inflammatory potency of Saharan dust - Gerrit Bredeck, IUF – Leibniz Research Institute for Environmental Medicine
9:20 - Characterization and in vitro toxicology of Subway PM - David Luglio, New York University
9:40 - Heavy metal-laden particulate exposure induces enteroendocrine expansion in adult human colonoids - Roger Atanga, University of New Mexico
10:00 - Coffee Break - Mezzanine
10:20 - Are ultrafine particles from aircraft of more concern compared to those from road traffic? - Flemming Cassee, PhD, RIVM
10:50 - Pulmonary Toxicity of Particulate Matter Emitted from Firearms - Ian Gilmour, US Environmental Protection Agency
11:10 - Interactive outcomes after ultrafine particle and ozone mixed inhalation exposures - Salik Hussain, West Virginia University
11:30 - The Importance of a Multidisciplinary Approach in Inhalation Toxicology - Danielle Carlin, NIEHS
11:50 - In Memorium – Remembering Jon Hotchkiss, Renaud Vincent, and Bruce Boecker - Roger McClellan
12:10 - Concluding remarks, Student Awards - Matthew Campen, Alexandra Noël
